Minimal Stimulation In Vitro Fertilization: A Better Outcome
نویسنده
چکیده
Royan Institute International Journal of Fertility and Sterility Vol 10, No 2, Jul-Sep 2016, Pages: 264-266 In in vitro fertilization (IVF) programme, the advantages of mild-stimulation have long been appreciated, while there was a called for more patient-friendly approach in ovarian stimulation around 20 years ago (1). However, the concept is yet to get wide-spread acceptance in the IVF community. The main impediment has been a lack of robust outcome data that can assure the success of mild-IVF at least as good as those of conventional IVF. The randomized controlled trials (RCTs) that compared sequential clomiphene citrate (CC) and low-dose gonadotropins (as mild/ minimal stimulation) with conventional long protocol were either small in sample size or heterogeneous in character (2). Nevertheless, recent meta-analyses and systematic reviews found no difference in pregnancy rates or live birth rates (LBRs) between sequential CC-gonadotropin protocol and conventional IVF (3, 4). More recently, a prospective cohort of 163 good prognosis patients undergoing IVF with sequential CC and low-dose gonadotropin regimen reported a cumulative-LBR (C-LBR) of 70% from a fresh and subsequent frozen embryo transfer (ET) up to 3 cycles (5). A large retrospective cohort study of 20, 244 cycles from Japan using a protocol comprising of extended CC (up to the trigger day)+gonadotropin and subsequent single vitrified-thawed ET found the treatment outcomes of in all age-groups were comparable with those in the Registry of the Society for Assisted Reproduction (SART) in the USA (6).
منابع مشابه
Minimal Stimulation In Vitro Fertilization: A Better Outcome
advantages of mild-stimulation have long been appreciated, while there was a called for more patient-friendly approach in ovarian stimulation around 20 years ago (1)...
متن کاملResurgence of Minimal Stimulation In Vitro Fertilization with A Protocol Consisting of Gonadotropin Releasing Hormone-Agonist Trigger and Vitrified-Thawed Embryo Transfer
Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are report...
متن کاملSeasonal Influences on Different Stages of In Vitro Fertilization: Stimulation and Fertilization
Background Effect of seasonal changes in human reproduction has been intensively researched. Some studies acknowledge influences of seasonal variation on natural conception, while others can not confirm them. The aim of this study was to investigate the effect of seasonal changes on different stages of assisted reproductive technology (ART) in Tehran. MaterialsAndMethods This study was carried ...
متن کاملO-30: The Correlation between Myometrial Thickness and In Vitro Fertilization/ Intracyto- Plasmic Sperm Injection (IVF/ ICSI) Outcomes
Background O-30: The Correlation between Myometrial Thickness and In Vitro Fertilization/ Intracyto- Plasmic Sperm Injection (IVF/ ICSI) Outcomes MaterialsAndMethods In this prospective cohort study, 453 infertile women undergoing IVF-ET/ICSI cycles without any obvious pathology of uterine were enrolled. Trans-vaginal ultrasounds were conducted on days 2-4 of the cycle (menstrual phase) precedi...
متن کامل